ACVRL1 (N-term) Peptide
产品名称: ACVRL1 (N-term) Peptide
英文名称: ACVRL1 (N-term) Peptide
产品编号: P2811
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
                            亚诺法生技股份有限公司(Abnova)
                            
                                
                            
                        
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- Specification
 
- Product Description:
 - Rabbit polyclonal antibody raised against synthetic peptide of ACVRL1.
 
- Immunogen:
 - A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human ACVRL1.
 
- Host:
 - Rabbit
 
- Reactivity:
 - Human, Mouse
 
- Form:
 - Liquid
 
- Purification:
 - Protein G purification
 
- Storage Buffer:
 - In PBS (0.09% sodium azide)
 
- Storage Instruction:
 - Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. 
- Recommend Usage:
 - ELISA (1:1000)
Western Blot (1:100-500)
Flow cytometry (1:10-50)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user. 
- Note:
 - This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
 
- Publication Reference
 
- 1.
 - LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells.
Yu MJ, Pisitkun T, Wang G, Shen RF, Knepper MA.Mol Cell Proteomics. 2006 Nov;5(11):2131-45. Epub 2006 Aug 9. 
- Applications
 
- Western Blot (Tissue lysate)
 
- Western blot analysis of ACVRL1 polyclonal antibody (Cat # PAB3475) in mouse heart tissue lysate.
 
- Western Blot (Transfected lysate)
 
- Western blot analysis of ACVRL1 polyclonal antibody (Cat # PAB3475) in human chondrocytes (C-28/I2 cells), transfected with empty vector (lane 1, 3) or ACVRL1 (lane 2, 4). RIPA lysis buffer, 20 ug/lane of protein, primary antibody dilution 1 : 1000, blocking solution is 5% milk in TBST (lane 1 and 2), 5% BSA in TBST (lane 3 and 4). Data courtesy of Kenneth Finnson, Montreal General Hospital.
 
- Western Blot (Transfected lysate)
 
- Western blot analysis of ACVRL1 (arrow) using rabbit ACVRL1 polyclonal antibody (Cat # PAB3475). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVRL1 gene (Lane 2) (Origene Technologies).
 
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
 
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with ACVRL1 polyclonal antibody (Cat # PAB3475) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma.
 
- Entrez GeneID:
 - 94
 
- Protein Accession#:
 - P37023
 
- Gene Name:
 - ACVRL1
 
- Gene Alias:
 - ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,SKR3,TSR-I
 
- Gene Description:
 - activin A receptor type II-like 1
 
- Gene Ontology:
 - Hyperlink
 
- Gene Summary:
 - This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq
 
- Other Designations:
 - TGF-B superfamily receptor type I,activin A receptor, type II-like kinase 1,serine/threonine-protein kinase receptor R3
 
- Related Disease
 
- Anemia, Sickle Cell
 - Anemia, sickle cell
 - Arteriovenous Malformations
 - Asthma
 - Asthma
 - Cardiovascular Diseases
 - Central Nervous System Vascular Malformations
 - Chromosome Aberrations
 - Diabetes Mellitus, Type 2
 - Edema
 - Epistaxis
 - Genetic Predisposition to Disease
 - Heart Diseases
 - Hyperparathyroidism, Secondary
 - Hyperplasia
 - Hypertension, Pulmonary
 - Intracranial Aneurysm
 - Intracranial Arteriovenous Malformations
 - Liver Cirrhosis
 

